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Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson’s disease model

✍ Scribed by Jae-Sun Choi; Mi Suk Lee; Joo-Won Jeong

Book ID
116300085
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
878 KB
Volume
394
Category
Article
ISSN
0006-291X

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN