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Ethyl {4-[2-(saccharin-2-yl)acetylsulfamoyl]phenylazo}cyanoacetate in the synthesis of polyfunctionally heteroaromatic derivatives

✍ Scribed by A. A. Aly

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
122 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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An efficient and direct one‐pot reaction of ethyl saccharinylcyanoacetate derivative 3 with a variety of active methylene reagents and nitrogen nucleophiles afforded novel series of polyfunctionally substituted heteroaromatic derivatives 5–13, respectively. The pyrazole derivative 13 was seemed to be the excellent precursors for the synthesis of pyrazolo[1,5‐a]pyrimidine derivatives 14–24. The antimicrobial screening of some synthesized products was evaluated against some selected bacteria and fungi. The structures of the synthesized derivatives were established by elemental and spectral data. J. Heterocyclic Chem., (2009).

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## Abstract __N__‐[4‐(Dicyanomethylazo)phenyl]‐2‐saccharin‐2‐ylacetamide (**__2__**) proved to be a convenient precursor for the synthesis of a variety of pyridazine and pyrimidine derivatives **__4a,b,6__**, and **__7__**. Also a series of substituted pyrimidines **__10–16__** were prepared from t