Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians
✍ Scribed by Toshinobu Fujiyoshi; Shinji Yashiki; Chihaya Fujiyama; Masahiro Kuwayama; Hiroki Miyashita; Hiroshi Ohnishi; Michelle Blank; Vladimir Zaninovic; Abraham Blank; Luis Cartier; John J. Byrnes; William J. Harrington Jr.; Tomoyuki Miura; Masanori Hayami; Kazuo Tajima; Shunro Sonoda
- Book ID
- 102866255
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 987 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HIA DRBI*-DQBl* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-carrying Andes natives had one of the 5 HLA haplotypes: DRB I *-DQB I * 0403-0302, 0802-0402, 090 1-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQB I * 1402-030 I, 1602-030 I and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-I1 carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These reults suggested that H I A haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.