𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ethnic differences in the anatomical location of colorectal adenomatous polyps

✍ Scribed by G. Johan A. Offerhaus; Francis M. Giardiello; Kasper W. F. Tersmette; Jan-Willem R. Mulder; Anne C. Tersmette; G. William Moore; Stanley R. Hamilton

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
529 KB
Volume
49
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The ratio of right‐ to left‐sided colonic cancer is increasing, but data on the distribution of its usual precursor lesion, the colorectal adenoma, are contradictory. Therefore, we investigated the prevalence of right‐ and left‐sided colorectal adeno‐matous polyps from January I, 1970, to September 30, 1989, using the study design of „epidemiologic necropsy”︁ and the autopsy files of The Johns Hopkins Hospital.

Compared with the decade of the 1970's, the 1980's showed a slight decrease in the overall prevalence of right‐sided adenomas (6.4 per 1,000, 95% confidence limits 4.7‐8.8 vs. 5.1 per 1.000, 95% CL 3.6‐6.5), but a marked decrease occurred in left‐sided adenomas (11.8 per 1,000,95% CL 9.3‐14.3 vs. 6.7 per 1,000, 95% CL 4.8‐8.6). As a result, the ratio of right‐sided to left‐sided adenomas increased from 0.55 in the 1970's to 0.77 in the 1980's. This increased ratio occurred in both sexes, although prevalences were lower in females, and in whites. Unexpectedly, blacks had a ratio of right‐sided to left‐sided adenomas greater than unity in both the 1970's and 1980's (1.19 vs. 1.79) due to a relatively high prevalence of right‐sided adenomas (5.8 per 1,000, 95% CL 3.6‐8.0 in 1970's; 5.8 per 1,000, 95% CL 3.3‐8.3 in 1980's), but low prevalences of left‐sided adenomas (4.9 per 1,000, 95% CL 3.0‐6.8 in 1970's; 3.2 per 1,000, 95% CL 1.2‐5.2 in 1980's). The overall adenoma prevalence in blacks was lower than in whites.

We conclude that the right‐sided predominance of colorectal adenomas in blacks suggests ethnic differences in the pathogenesis of colorectal adenomas. This observation may have important implications for secondary prevention of colorectal cancer.

📜 SIMILAR VOLUMES

Pattern of cell kinetics in colorectal m
Pattern of cell kinetics in colorectal mucosa of patients with different types of adenomatous polyps of the large bowel
✍ Luca Roncucci; Alessandra Scalmati; Maurizio Ponz De Leon 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 563 KB

It is generally accepted that adenomatous polyps represent the natural precursor of many colorectal malignancies. The sequence, however, which leads from a normally appearing mucosa to cancer is complex and involves many steps, including a hyperproliferative mucosa with an upward expansion of the re

Rectal cell proliferation and colorectal
Rectal cell proliferation and colorectal cancer risk level in patients with nonfamilial adenomatous polyps of the large bowel
✍ Gian Maria Paganelli; Guido Biasco; Renato Santucci; Giovanni Brandi; Alfredo An 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB 👁 2 views

The authors evaluated cell kinetics of apparently normal rectal mucosa in the following subjects: 25 with single small adenoma (smaller than 10 mm) of the large bowel, 12 with multiple small adenomas, 28 with a single large adenoma (larger than 10 mm), 22 bearing multiple adenomas among which at lea

Nuclear accumulation of p53 in colorecta
Nuclear accumulation of p53 in colorectal adenocarcinoma : Prognostic importance differs with race and location of the tumor
✍ Upender Manne; Heidi L. Weiss; Russell B. Myers; Omar K. Danner; Cecilia Moron; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB 👁 2 views

## BACKGROUND. Although several studies have been conducted to examine the role of p53 genetic abnormalities and their prognostic value in colorectal carcinoma, the incidence of nuclear accumulation of p53 and the prognostic importance of nuclear accumulation of p53 in African-American and white p

Colorectal cancers show distinct mutatio
Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability
✍ Cristina Albuquerque; Célia Baltazar; Bruno Filipe; Filipa Penha; Teresa Pereira 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 962 KB

## Abstract It is unclear whether the mutation spectra in WNT genes vary among distinct types of colorectal tumors. We have analyzed mutations in specific WNT genes in a cohort of 52 colorectal tumors and performed a meta‐analysis of previous studies. Notably, significant differences were found amo