Ethanolamine and phosphonic acid complexes in heat-treated Tetrahymena cells

Impaired secretion and increased insolub

Impaired secretion and increased insolubilization of IgE-receptor complexes in mycophenolic acid-treated (guanine nucleotide-depleted) RBL-2H3 mast cells

✍ Bridget Smith Wilson; Jeanclare Seagrave; Janet M. Oliver 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 584 KB

In RBL-2H3 rat leukemic mast cells, cross-linking anti-DNP IgE-receptor complexes with multivalent antigen (DNP-BSA) activates a signal transduction pathway leading to Ca2+ influx and secretion. Cross-linking IgE-receptor complexes also stimulates a pathway that inactivates (desensitizes) receptors;