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Ethanol-Mediated DNA Damage and PARP-1 Apoptotic Responses in Cultured Fetal Cortical Neurons

โœ Scribed by Priscilla P. Cherian; Steven Schenker; George I. Henderson

Book ID
109124143
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
959 KB
Volume
32
Category
Article
ISSN
0145-6008

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โœ Vinitha Ramachandran; Lora Talley Watts; Shivani Kaushal Maffi; Juanjuan Chen; S ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 503 KB

## Abstract In utero ethanol exposure elicits apoptotic cell death in the fetal brain, and this may be mediated by oxidative stress. Our studies utilize cultured fetal rat cortical neurons and illustrate that ethanol elicits a rapid onset of oxidative stress, which culminates in mitochondrially med