Ethanol influences on the chick embryo spinal cord motor system. II. Effects of neuromuscular blockade and period of exposure
✍ Scribed by Bradley, Douglas M. ;Beaman, Francesca D. ;Moore, D. Blaine ;Heaton, Marieta Barrow
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 196 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
The study described below was perneurons and reduced motoneuron number in the abformed as a continuation of a previous study in which sence of NOCD. By administering ethanol from E10 we found reduced motoneuron number in lumbar spito E15 and examining the lumbar spinal cord on E16, nal cord of the chick embryo following chronic ethanol we determined that ethanol can reduce motoneuron administration from embryonic day 4 (E4) to E11. number without altering spinal cord length during We sought to determine whether this reduction was more than one stage of chick embryo development, due to primary ethanol toxicity or to enhancement of and that ethanol toxicity is not dependent on NOCD. naturally occurring cell death (NOCD) and to deter-In addition, we demonstrated that ethanol does not mine whether administration of ethanol at a later peaffect the neurotrophic content of chick muscle when riod of development could also reduce motoneuron it is administered from E10 to E15. ᭧ 1997 John Wiley & number. Earlier studies have shown that curare sus-