Ethanol-induced increase in portal hepatic blood flow: Interference by anesthetic agents
✍ Scribed by Frederick J. Carmichael; Victor Saldivia; Yedy Israel; John P. McKaigney; Hector Orrego
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 662 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
While a number of studies show that acute oral adminitstration of ethanol results in increases in liver blood flow, a large body of evidence has also been presented in which such an effect is not observed. To shed light on thie discrepancy, we have studied in rats, a number of varioMes that might modulate or inhibit the effect of ethanol. These included the use of three anesthetic agents studied at two different times after anesthetic adminiatration and the effect of animal age, gender, batches and aeasonal variation.
Portal blood flows were determined by the radiolabeled microsphere method in 12 separate experiments in awake rats. Ethanol given at dosee ranging from 0.5 to 4.0 gm per kg consistently increased portal vein blood flow by approximately 50% (42.2 2 3.5 to 63.4 f 6.5 ml per min per kg). The interexperiment variation was 2.4
to 3.0%, ohowing remarkable consistency, typical of an all-or-none effect at the doses employed. On the other hand, the ethanol-induced increase in portal blood flow wm completely suppressed by ketamine (75 mg per kg), thiopemtal (50 mg per kg) and fentanyl (15 pg per kg) when given 15 min prior to blood flow determinations.