T cell activation-induced and HIV Tat-en
T cell activation-induced and HIV Tat-enhanced CD95(APO-1 / Fas) ligand transcription involves NF-κB
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Min Li-Weber; Oskar Laur; Kirsten Dern; Peter H. Krammer
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Article
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2000
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John Wiley and Sons
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English
⚖ 191 KB
👁 1 views
CD95(APO-1/Fas) ligand (CD95L) gene expression is critically involved in activation-induced T cell apoptosis. We and other have previously shown that HIV-1 Tat which is essential for efficient HIV gene expression sensitizes CD95-mediated apoptosis and up-regulates CD95L expression in T cells. In the