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Ethanol-enhanced transmembrane penetration of arachidonic acid and activation of the 5-lipoxygenase pathway in human leukocytes

✍ Scribed by Floyd A. Green; Hans-Erik Claesson


Book ID
115759620
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
415 KB
Volume
140
Category
Article
ISSN
0006-291X

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✍ L. Iversen; K. Fogh; K. Kragballe πŸ“‚ Article πŸ“… 1992 πŸ› Springer-Verlag 🌐 English βš– 478 KB

The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (