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Ethanol and H2-receptor antagonists

✍ Scribed by Mack C. Mitchell; James J. Potter; Esteban Mezey; Helmut K. Seitz; Siegrid Veith; Peter Czygan; Johann Bösche; Bernd Simon; Burkhard Simon; Roland Gugler

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
252 KB
Volume
5
Category
Article
ISSN
0270-9139

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✦ Synopsis

Since different forms of cytochrome P-450 are involved in the microsomal oxidation of ethanol and other substrates, such as aminopyrine, we were interested in whether cimetidine inhibits microsomal ethanol-oxidizing system (MEOS).

We determined the hepatic effect of cimetidine on the alcohol dehydrogenase and MEOS activities in uitro and on rates of ethanol elimination. Hepatic cytosol and microsomal fractions were obtained from male Sprague-Dawley rats and the determinations done as Dreviously described (1). The enzyme activities were assayed in the presence of cimetidine concentrations ranging between 0 and 5 mM. Cimetidine added in uitro did not alter the activities of either alcohol dehydrogenase or MEOS even at high ( 5 mM) concentrations. The inhibitory constant K, for the effects of cimetidine on other microsomal oxidations has been reported to be in the range of 0.1 to

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