Ethanol and behavioral variability in the radial-arm maze
โ Scribed by L. D. Devenport; V. J. Merriman
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 389 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
โฆ Synopsis
Ethanol (0.75, 1.5, 2.0 g/kg ethyl alcohol) consistently and profoundly narrowed three independent dimensions of behavioral variability (BV) exhibited by rats in an eight-arm radial maze. Thie was true for all doses except the lowest. Rats were run with a replacement procedure wherein rewards (two food pellets) were replaced after they were taken. With no constraints against where, how, or by what route rewards could be taken, the three indices of spontaneous BV recorded were the number of different arms chosen, the sequence of visitation, and instances of deviations from goal-directed activity. The behavior of saline and low-dose groups was widely variable in form and place; and the sequence of behavior was relatively unpredictable from trial to trial and from session to session. Medium and high doses of ethanol exerted a marked organizing influence on behavior. Superfluous topographies were eliminated, sequences became highly, and in many cases perfectly predictable, and spatial BV declined. The considerable promotion of stereotypy by ethanol helps to explain many effects of the drug, e.g., how the drug can in some instances impair, and in others facilitate performance. We propose that the scores from tasks whose mastery entails repetition, few topographies, and rigid structure will be improved by ethanol, but that those requiring change and the sampling of new strategies will be impaired.
๐ SIMILAR VOLUMES
I n rats, the effects of an intracerebroventricular (ICV) nicotinic agonist nicotine (NIC), the nicotinic antagonist mecamylamine (MEC), and combinations of NIC + MEC were assessed in a radial-arm maze (RAM). In experiment 1, exploratory behavior was assessed in untrained rats (N = 13). The rats rec
Chronic oral administration of cannabis extract to rats (daily A 9-tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radialarm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treate
Hypoxia has generally been reported to impair learning and memory. Here we established a hypoxia-enhanced model. Intermittent hypoxia (IH) was simulated at 2 km (16.0% O2) or 5 km (10.8% O2) in a hypobaric chamber for 4 h/day from birth to 1, 2, 3, or 4 week(s), respectively. Spatial learning and me