Estrogens, regulation of p53 and breast cancer risk: a balancing act
β Scribed by D. Joseph Jerry; Karen A. Dunphy; Mary J. Hagen
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 314 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1420-682X
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## Abstract In 511 nulliparous women aged 15β19 years and 347 aged 30β39, an analysis has been undertaken of the relationship of urine concentrations of the three principal estrogens to age, age at menarche and Quetelet's index of adiposity. The analysis was undertaken by means of multiple regressi
## Abstract Recent studies have shown that only breast cancer epithelial cells with intact p53 can induce metallothionein (MT) synthesis after exposure to metals. In this study, the potential role of p53 on regulation of MT was investigated. Results demonstrate that zinc and copper increased metal