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Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability

✍ Scribed by V Breinholt; A Hossaini; G.W Svendsen; C Brouwer; S.E Nielsen

Book ID: 117449621
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 281 KB
Volume: 38
Category: Article
ISSN: 0278-6915
DOI: 10.1016/s0278-6915(00)00046-6

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In the mouse, ovariectomy (OVX) leads to signi®cant reductions in cancellous bone volume while estrogen (17b-estradiol, E2) replacement not only prevents bone loss but can increase bone formation. As the E2dependent increase in bone formation would require the proliferation and differentiation of os