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Estrogenic action of β-HCH through activation of c-Neu in MCF-7 breast carcinoma cells

✍ Scribed by Mariko Hatakeyama; Daniel M Tessier; Debra Y Dunlap; Enmin Zou; Fumio Matsumura

Book ID
117766099
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
316 KB
Volume
11
Category
Article
ISSN
1382-6689

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## Abstract In this study, we compared the estrogenic action pattern of β‐HCH to another ErbB2 activating agent, heregulin β1 (HRG), along with 17β‐estradiol and epidermal growth factor, to understand the similarities and differences of their action mechanisms. Not surprisingly, most of the initial

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It has been suggested that there is a positive correlation between increased incidence of breast cancer and the presence of organochlorine residues such as DDT and HCH in breast tissues in the United States. To study possible biochemical links between these two parameters, we have examined the effec