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Estrogen-signaling pathway: A link between breast cancer and melatonin oncostatic actions

✍ Scribed by Samuel Cos; Alicia González; Carlos Martínez-Campa; Maria Dolores Mediavilla; Carolina Alonso-González; Emilio J. Sánchez-Barceló


Book ID
113524348
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
438 KB
Volume
30
Category
Article
ISSN
0361-090X

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The responsiveness of estrogen receptor (ER)-positive breast cancer to endocrine therapy is frequently reduced in cells over-expressing c-erbB-2. Stimulation of ER suppresses c-erbB-2, indicating that estrogen controls the activity of c-erbB-2. Heregulin (HRG) has been described to bind to c-erbB-3/