Estrogen replacement therapy is associated with less progression of subclinical structural brain disease in normal elderly women: a pilot study
✍ Scribed by Ian A. Cook; Melinda L. Morgan; Jennifer J. Dunkin; Steven David; Elise Witte; Robert Lufkin; Michelle Abrams; Susan Rosenberg; Andrew F. Leuchter
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 186 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0885-6230
- DOI
- 10.1002/gps.644
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
Cortical atrophy, central atrophy, deep white-matter hyperintensities, and periventricular hyperintensities are reported in normal aging.
Objectives:
We examined the effects of estrogen replacement therapy (ert) on these forms of 'subclinical structural brain disease' (ssbd) in normal, postmenopausal women in a pilot, naturalistic, longitudinal study of 15 subjects.
Methods:
Two assessments were performed at least two years apart, with volumetric magnetic resonance imaging (mri) and neuropsychological testing.
Results:
Women receiving open-label ert showed significantly less progression of ssbd than those who did not.
Conclusions:
The association between reduced ssbd progression and ert suggests this intervention could help preserve normal brain structure in healthy elderly women.