Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells
β Scribed by H Rochefort; D Chalbos; S Cunat; A Lucas; N Platet; M Garcia
- Book ID
- 117668081
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 82 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0960-0760
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In an attempt to understand the mechanism by which estrogens stimulate cell proliferation and mammary carcinogenesis, metastatic human breast cancer cell lines (MCF7, ZR75-1) were found to secrete a 52,000 dalton (52K) protein under estrogen stimulation. Following its purification to homogeneity, th
## Abstract The cyclinβdependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30β60βmin independent of new protein synthesis in the estrogen recept