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Estrogen receptor α-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene

✍ Scribed by Lemieux, C; Phaneuf, D; Labrie, F; Giguère, V; Richard, D; Deshaies, Y


Book ID
110045857
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
345 KB
Volume
29
Category
Article
ISSN
1476-5497

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Acolbifene (EM-652 Á HCl, SCH 57068 Á HCl), a highly potent and orally active selective estrogen receptor modulator (SERM), is at late stage clinical development for the treatment of estrogen-sensitive breast cancer. Acolbifene-7-glucuronide 1 (major) and acolbifene-4 0 -glucuronide 2 (minor) were i