Estrogen Receptor Beta (ESR2) Polymorphisms in Familial and Sporadic Breast Cancer
✍ Scribed by Paula Maguire; Sara Margolin; Johanna Skoglund; Xiao-Feng Sun; Jan-Åke Gustafsson; Anne-Lise Børresen-Dale; Annika Lindblom
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 190 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Estrogens, and to a lesser extent progesterones, influence the proliferation, differentiation and physiology of breast tissue as well as the development and progression of breast cancer. Genetic variants in the steroid hormone receptor genes __ESR1__ and __PGR__ (belonging to the nuclea
## Abstract Exposure to exogenous (oral contraceptives, postmenopausal hormone therapy) and endogenous (number of ovulatory cycles, adiposity) steroid hormones is associated with breast cancer risk. Breast cancer risk associated with these exposures could hypothetically be modified by genes in the
It is fairly well accepted that the presence of estrogen receptor (ER) identifies those breast cancer patients with a lower risk of relapse and better overall survival [Clark and McGuire, 19881, and the measurement of ER has become a standard assay in the clinical management of breast cancer. Recept