## Abstract Estrogens exert their effect on the breast through the estrogen receptor. We prospectively investigated breast cancer risk associated with 2 polymorphic sites in the estrogen receptor alpha gene (__ESR1__). A total of 4,248 Caucasian women from the Study of Osteoporotic Fractures were g
Estrogen receptor alpha haplotypes and breast cancer risk in older Caucasian women
β Scribed by Jun Wang; Russell Higuchi; Francesmary Modugno; Jia Li; Nanette Umblas; Jocelyn Lee; Li-Yung Lui; Elad Ziv; Jeffery A. Tice; Steven R. Cummings; Brian Rhees
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 179 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Exposure to exogenous (oral contraceptives, postmenopausal hormone therapy) and endogenous (number of ovulatory cycles, adiposity) steroid hormones is associated with breast cancer risk. Breast cancer risk associated with these exposures could hypothetically be modified by genes in the
## Abstract ## BACKGROUND Genes encoding enzymes involved in estrogen metabolism are held to be candidate genes for associations with breast disease. In these candidate genes, no critical combination of singleβnucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to