In the mouse, ovariectomy (OVX) leads to signi®cant reductions in cancellous bone volume while estrogen (17b-estradiol, E2) replacement not only prevents bone loss but can increase bone formation. As the E2dependent increase in bone formation would require the proliferation and differentiation of os
✦ LIBER ✦
Estrogen modulates osteogenic activity and estrogen receptor mRNA in mesenchymal stem cells of women
✍ Scribed by Chen, F.-P.; Hu, C.-H.; Wang, K.-C.
- Book ID
- 121262123
- Publisher
- Informa plc
- Year
- 2012
- Tongue
- English
- Weight
- 326 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1369-7137
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## Abstract The aim of this study was to investigate the osteogenic induction by tacrolimus hydrate (FK506) of rat bone marrow‐derived mesenchymal stem cells (MSCs). MSCs were cultured in α‐MEM containing either (1) L‐ascorbic acid‐2‐phosphate (AsAP) and β‐glycerophosphate (β‐GP) as a control; (2)