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Estrogen binding sites on membranes from human laryngeal papilloma

✍ Scribed by Eric J. Essman; Alan Abramson

Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 451 KB
Volume: 33
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910330107

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✦ Synopsis

Abstract

Estrogen binding sites were identified on plasma membranes from biopsy materials (N=16) of normal human larynx; such binding was found to be specific. In tissue from 22 cases of laryngeal papilloma, membrane binding of 17‐beta‐estradiol was also specific. Although such binding occurred for papilloma membranes at a comparable affinity, it was clear that all membranes from the papillomatous tissue possessed a 148% greater estrogen binding capacity; there were at least 17 times more estrogen binding sites for each mg of receptor protein on papilloma membrane than for normal laryngeal epithelium. These findings suggest a possible receptor marker for the detection and/or prediction of recurrence of laryngeal papilloma.

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