Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells
✍ Scribed by Jose Russo; M. Hasan Lareef; Gabriela Balogh; Shanchun Guo; Irma H. Russo
- Book ID
- 117668660
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 885 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0960-0760
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## Abstract An elevated incidence of breast cancer in women has been associated with prolonged exposure to high levels of estrogens. Our laboratory demonstrated that treatment of the immortalized human breast epithelial cells MCF‐10F with 17β‐estradiol (E~2~), 4‐hydroxyestradiol (4‐OHE~2~) or 2‐hyd
## Abstract Estrogens promote cell proliferation in normal and transformed mammary epithelial cells by inducing expression of hormone‐responsive genes involved in the cell cycle. The action of antiestrogens is therefore central in regard to their potent inhibitory effects on estrogen‐induced cell g