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Estramycins: a potential acyclic diyl precursor derived from estradiol

โœ Scribed by Wang Jing; Pierre J. De Clercq

Book ID
103404599
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
265 KB
Volume
37
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES

Estramicins: a novel cyclic diyl precurs
Estramicins: a novel cyclic diyl precursor derived from estradiol
โœ Christel Meert; Jing Wang; Pierre J. De Clercq ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 297 KB

The estradiol derived ynone 2 is obtained via a 13 step sequence starting from estrone. One of the key-steps involves the addition to estrone derivative 3 of the lithio derivative 8. Obtention of the latter in enantiomericaUy pure form involves the lipase mediated kinetic resolution of racemic alcoh