𝔖 Bobbio Scriptorium
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Estramustine phosphate—historical overview

✍ Scribed by H. Fex; B. Högberg; I. Könyves


Book ID
119486039
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
168 KB
Volume
23
Category
Article
ISSN
0090-4295

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The preparation of estromustine (EoM), estramustine (EaM) and estramustine phosphate (EMP) specifically labelled with deuterium is reported. A two-step, one-pot procedure based on the reaction of N,N-bis(2-chloroethyl)carbamoyl chloride with the commercially available [2,4,16, H 4 ]estrone (1) or [2