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Estimation of the rate and extent of chiral inversion using linear systems analysis

โœ Scribed by Andrew J. McLachlan; Kenneth M. Williams

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
425 KB
Volume
7
Category
Article
ISSN
0899-0042

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โœฆ Synopsis

An alternative method based on linear systems analysis is presented for the analysis of concentration-time data for the enantiomers of the 2-arylpropionic acids. This approach uses deconvolution to estimate the rate and extent of c h a l inversion with respect to time, assuming linear pharmacokinetics and time invariance, without the need for complicated modelling procedures. Application to data for the chiral inversion of ibuprofen in the rat indicates that this approach provides a valid alternative to previous procedures for the analysis of chiral inversion data.

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