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Estimation of the Interindividual Variability in the One-Compartment Pharmacokinetic Model for Methylmercury: Implications for the Derivation of a Reference Dose

โœ Scribed by Alan H. Stern


Book ID
115646700
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
197 KB
Volume
25
Category
Article
ISSN
0273-2300

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Equations for the fraction of bioavailab
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In a recent paper,' we reported an equation for the calculation of the fraction of the bioavailable dose remaining in the body at t,,, Fsys,l,,, assuming that the drug follows one-compartment model disposition and first-order absorption. It was shown' that this fraction is solely dependent on the ra