Estimation of the extent of drug–excipient interactions involving croscarmellose sodium
✍ Scribed by R. Gary Hollenbeck; Krongtong T. Mitrevej; Allan C. Fan
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 308 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Prepared on Dowex 5 0 Na+ and Dowex 50 Ag+. 10 Prepared from 3'-0-acetyl-2'-deoxy-5-fluorouridine in 65% yield, according to the general procedure described previously (4).
prevented the growth of Chinese hamster ovary cells in culture ( 5) at a concentration of 5.0 X M (5-fluoro-2'-deoxyuridine control, 1.0 X M ) . Further chemical and biological studies of these compounds are in progress.
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Oral administration is the most desirable route of drug delivery for systemically active drugs. Oral drugs must possess a certain level of oral bioavailability, which is a product of oral absorption and first-pass effect. Low oral bioavailability may be attributed to poor absorption and/or high firs