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Estimation of serum protein binding of compounds metabolized in serum using matrix inhibition

✍ Scribed by Takahide Uchimura; Motohiro Kato; Rie Shiokawa; Yoshiaki Nabuchi; Kimitoshi Saito; Haruki Kinoshita


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
74 KB
Volume
29
Category
Article
ISSN
0142-2782

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The purpose of this study was to develop a method for estimating the hepatic clearance (CL(h)) without using a protein binding test. This method allows the simultaneous evaluation of the intrinsic hepatic clearance (CL(int)) with a correction for microsomal binding, and the free fraction in the seru