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Estimation of Pairwise Relationships in the Presence of Genotyping Errors

✍ Scribed by Karl W. Broman; James L. Weber

Book ID: 117852609
Publisher: American Society of Human Genetics
Year: 1998
Tongue: English
Weight: 38 KB
Volume: 63
Category: Article
ISSN: 0002-9297
DOI: 10.1086/302112

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## Abstract Errors in genotyping can greatly affect family‐based association studies. If a mendelian inconsistency is detected, the family is usually removed from the analysis. This reduces power, and may introduce bias. In addition, a large proportion of genotyping errors remain undetected, and th