✦ LIBER ✦
Estimation of linkage disequilibrium from conditional haplotype data: Application to β-globin gene cluster in American blacks
✍ Scribed by Dr. Ranajit Chakraborty; D. C. Rao
- Book ID
- 102843672
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 595 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
Simple estimators of gene frequencies and linkage disequilibria are proposed when haplotype data are available from four parental chromosomes of a child (or fetus) for whom genetic counseling is sought for a disease condition. The method is illustrated with restriction site polymorphisms associated with sickle-cell anemia (Hb-p') gene as surveyed in genetic counseling data from American blacks. The method suggested here is shown to be useful in testing for the significance of interactions of site-specific variations of any order in the chromosomal region assayed.