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Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters

✍ Scribed by Patrick J. Marsac; Tonglei Li; Lynne S. Taylor

Book ID
106493560
Publisher
Springer US
Year
2008
Tongue
English
Weight
271 KB
Volume
26
Category
Article
ISSN
0724-8741

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📜 SIMILAR VOLUMES

Drug–polymer solubility and miscibility:
Drug–polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development
✍ Feng Qian; Jun Huang; Munir A. Hussain 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB

Drug-polymer solid dispersion has been demonstrated as a feasible approach to formulate poorly water-soluble drugs in the amorphous form, for the enhancement of dissolution rate and bioperformance. The solubility (for crystalline drug) and miscibility (for amorphous drug) in the polymer are directly