Estimation of D2-like dopamine receptor occupancy by dopamine in the MPTP primate model of Parkinson's disease
β Scribed by Svetlana Chefer; A Kimes; E Domino; E London; A Mukhin
- Book ID
- 118490050
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 56 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1053-8119
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L-dopa remains the most common treatment for Parkinson's disease. However, there is considerable interest in D3/D2 receptor agonists such as the novel agent S32504, since they exert antiparkinsonian properties in the absence of dyskinesia. An important question concerns the roles of D2 vs. D3 recept
## Abstract Investigation of the pathophysiology of psychosis in Parkinson's disease (PD), as well as the assessment of potential novel therapeutics, has been limited by the lack of a wellβvalidated animal model. MPTPβlesioned primates exhibit abnormal behaviors that are distinct from dyskinesia an