Estimation of chromium-51 ethylene diamine tetra-acetic acid plasma clearance: a comparative assessment of simplified techniques

✍ Scribed by Giuseppe Picciotto; Giovanni Cacace; Patrizia Cesana; Roberto Mosso; Roberto Ropolo; P. Giuseppe Filippi

• Book ID: 104652635
• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 538 KB
• Volume: 19
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00178305

✦ Synopsis

Chromium-51 ethylene diamine tetra-acetic acid (51Cr-EDTA) total plasma clearance was evaluated using a multi-sample method (i.e. 12 blood samples) as the reference compared with several simplified methods which necessitated only one or few blood samples. The following 5 methods were evaluated: terminal slope-intercept method with 3 blood samples, simplified method of Br6chner-Mortensen and 3 single-sample methods (Constable, Christensen and Groth, Tauxe). Linear regression analysis was performed. Standard error of estimate, bias and imprecision of different methods were evaluated. For 51Cr-EDTA total plasma clearance greater than 30ml.min -1, the results which most approximated the reference source were obtained by the Christensen and Groth method at a sampling time of 300 min (inaccuracy of 4.9%). For clearances between 10 and 30 ml.min -I, single-sample methods failed to give reliable results. Terminal slope-intercept and Br6chner-Mortensen methods were better, with inaccuracies of 17.7% and 16.9%, respectively. Although sampling times at 180, 240 and 300 min are time-consuming for patients, 51Cr-EDTA total plasma clearance can be accurately calculated for values greater than 10 ml.min-1 using the Br6ehner-Mortensen method. In patients with clearance greater than 30 ml. min-1, singlesample techniques provide a good alternative to the multi-sample method; the choice of the method to be used depends on the degree of accuracy required.