Estimation of blood lead values from blood porphyrin and urinary 5-aminolevulinic acid levels in workers

Aminolevulinic acid dehydratase genotype

Aminolevulinic acid dehydratase genotype mediates plasma levels of the neurotoxin, 5-aminolevulinic acid, in lead-exposed workers

✍ Pornchai Sithisarankul; Brian S. Schwartz; Byung-Kook Lee; Karl T. Kelsey; Paul 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB 👁 2 views

The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid dehydr