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Estimation of agonist affinity, using the slope of the concentration-effect curve: comment on the method of Calderone and Martinotti

✍ Scribed by Piet H. Van der Graaf

Book ID
114343341
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
113 KB
Volume
40
Category
Article
ISSN
1056-8719

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## Abstract Risk assessments of toxic chemicals currently rely heavily on the use of no‐observed‐effect concentrations (NOECs). Due to several crucial flaws in this concept, however, discussion of replacing NOECs with statistically estimated low‐effect concentrations continues. This paper describes