Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration

In vivo evaluation of the semi-simultane

In vivo evaluation of the semi-simultaneous method for bioavailability estimation using controlled intravenous infusion as an ‘extravascular’ route of administration

✍ Ulf Bredberg; Mats O. Karlsson 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 749 KB

A recently proposed method for bioavailability estimation, called the semi-simultaneous method, was evaluated in vivo in rats using methysergide as a test substance. In this method the test and the reference dose are administered with a short time interval and a model including the bioavailability p