Estimating the uncertainty of binary test results to assess their compliance with regulatory limits

✍ Scribed by A. Pulido; I. Ruisánchez; R. Boqué; F.X. Rius

• Publisher: Elsevier Science
• Year: 2002
• Tongue: English
• Weight: 138 KB
• Volume: 455
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/s0003-2670(01)01604-x

✦ Synopsis

A procedure to calculate the uncertainty associated to a binary response, of the type yes/no, originated from an instrumental screening system, is described. Useful equations have been developed based on statistical intervals, and their validation were performed with standard commercial solution. It was applied to a differential pulse anodic stripping voltammetry (DPASV) screening system to analyse tap water, specifically, for determining Pb 2+ and Cd 2+ above the UE legislation limits, 10 and 5 g/l, respectively. A cut-off value from the responses of the calibration samples is calculated and compared with the responses obtained for unknown samples. From this comparison, we will be able to take a compliance yes/no decision, with an alpha probability of committing a type I error. Another parameter, r screening , is calculated in order to compare different methods for the same screening application.