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Estimating the total number of protein folds

✍ Scribed by Sridhar Govindarajan; Ruben Recabarren; Richard A. Goldstein

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 116 KB
Volume: 35
Category: Article
ISSN: 0887-3585
DOI: 10.1002/(sici)1097-0134(19990601)35:4<408::aid-prot4>3.0.co;2-a

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✦ Synopsis

Many seemingly unrelated protein families share common folds. Theoretical models based on structure designability have suggested that a few folds should be very common while many others have low probability. In agreement with the predictions of these models, we show that the distribution of observed protein families over different folds can be modeled with a highly-stretched exponential. Our results suggest that there are approximately 4,000 possible folds, some so unlikely that only approximately 2,000 folds existing among naturallyoccurring proteins. Due to the large number of extremely rare folds, constructing a comprehensive database of all existent folds would be difficult. Constructing a database of the most-likely folds representing the vast majority of protein families would be considerably easier.

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