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Estimating the ratio of CD4+ to CD8+ T cells using high-throughput sequence data

✍ Scribed by Emerson, Ryan; Sherwood, Anna; Desmarais, Cindy; Malhotra, Sachin; Phippard, Deborah; Robins, Harlan


Book ID
120052055
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
931 KB
Volume
391
Category
Article
ISSN
0022-1759

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Background: Until recently, there were no CD3 antibodies that crossreacted with rhesus macaque T cells. Consequently, studies relying on CD8 counts or CD4/CD8 ratios enumerated this subpopulation on the basis of CD8Ο© or CD8brightΟ© staining. We used a rhesus-specific, anti-CD3 antibody to better defi