A limited sampling method to estimate me
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F. Bressolle; L. Edno; C. Bologna; J. Sany; J. C. Bernard; B. Combe; R. Gomeni
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Article
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1996
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Springer
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English
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This paper describes a methodology to calculate methotrexate (MTX) pharmacokinetic parameters after intramuscular administration using two samples and the population parameters. Total and free MTX were measured over a 36-h period in 56 rheumatoid arthritis patients; 14 patients were studied after a