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Estimating skin permeation. The validation of five mathematical skin permeation models

✍ Scribed by Annette Wilschut; Wil F. ten Berge; Peter J. Robinson; Thomas E. McKone


Book ID
116080287
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
994 KB
Volume
30
Category
Article
ISSN
0045-6535

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The permeation coefficient characterizes the ability of a chemical to penetrate the dermis, and the current study describes our efforts to develop structure-based models for the permeation coefficient. Specifically, we have integrated nonlinear, quantitative structure-property relationship (QSPR) mo