## Abstract Pedigrees collected for linkage studies are a valuable resource that could be used to estimate genetic relative risks (RRs) for genetic variants recently discovered in caseβcontrol genome wide association studies. To estimate RRs from highly ascertained pedigrees, a pedigree βretrospect
Estimating genotype relative risks
β Scribed by G. MARK LATHROP
- Book ID
- 115093503
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 336 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0001-2815
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π SIMILAR VOLUMES
In mapping diseases of complex aetiology, conventional linkage approaches narrow the location of the disease susceptibility locus to quite a large region so that candidate gene association studies are then necessary to further isolate these genes. However, even in the simplest scenario where the can
## Abstract __Purpose__: To develop a method of genetic risk categorization based on the risk conferred by genetic variants and the precision with which risks are known. __Methods__: We develop a method for risk assignment based on an βaverageβ member of the population and their genotype, deriving