✦ LIBER ✦

Estimating familial effects on age at onset and liability to schizophrenia. I. Results of a large sample family study

✍ Scribed by Dr. Kenneth S. Kendler; Charles J. MacLean; D. C. Rao

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 541 KB
Volume: 7
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370070603

No coin nor oath required. For personal study only.

✦ Synopsis

Previous analyses of age at onset in schizophrenia, which is highly variable and appears to be influenced by familial factors, have neglected to consider either (1) the impact of censoring on correlations in age at onset in affected relatives or (2) the impact of correlated ages at onset on the relationship between age at onset in the proband and risk in relatives. In this report, using methods outlined in the companion paper [MacLean et al., Genet Epidemiol7:419-426, 19901 we examine these questions in the large family data set of schizophrenia collected by Lindelius [Acta Psychiat Scand (Suppl) 2 16: 1 -125, 19701. Ages at onset are positively correlated in pairs of affected relatives (parent-offspring siblings > nieceshephews) and these correlations are substantially higher after correction for censoring. Early age at onset is associated with higher risk of illness in siblings and nieceshephews but not in children. These results are consistent with the hypothesis that age at onset in schizophrenia is influenced by familial factors which are probably genetic and which are mostly unrelated to factors influencing disease liability.

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