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Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[14C]DTPA

✍ Scribed by Knight, Robert A; Karki, Kishor; Ewing, James R; Divine, George W; Fenstermacher, Joseph D; Patlak, Clifford S; Nagaraja, Tavarekere N

Book ID: 109871238
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 272 KB
Volume: 29
Category: Article
ISSN: 0271-678X
DOI: 10.1038/jcbfm.2009.20

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## Abstract The ability of gadolinium‐diethylenetriaminepentaacetic acid (Gd‐DTPA) enhanced MRI to localize and quantitate blood–brain barrier (BBB) opening was evaluated against quantitative autoradiographic (QAR) imaging of ^14^C‐α‐aminoisobutyric acid (AIB) distribution. The blood‐to‐brain trans