✦ LIBER ✦

Estimating bioavailability when clearance changes in time: The effect of model misspecification*

✍ Scribed by Fattinger, Karin E.; Verotta, Davide

Publisher: Nature Publishing Group
Year: 1995
Tongue: English
Weight: 522 KB
Volume: 58
Category: Article
ISSN: 0009-9236
DOI: 10.1016/0009-9236(95)90181-7

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✦ Synopsis

proposed a method to obtain estimates of a drug's (1) disposition function, (2) extravascular input function, (3) between-subject variability in disposition, and (4) within-subject interoccasion variability in disposition (e.g., in clearance) from data where a drug is given to the same group of people in two occasions: intra-