Esterase Activities and Soman Toxicity in Developing Rat
β Scribed by Sterri, Sigrun H. ;Berge, Gunnar ;Fonnum, Frode
- Book ID
- 114800455
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1985
- Weight
- 326 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0001-6683
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Male Sprague-Dawley rats, injected with the irreversible acetylcholinesterase (AChE) inhibitor soman (pinacolyl methylphosphonofluoridate) 25 micrograms/kg sc, showed no signs of toxicity. Pretreatment with iso-OMPA (tetraisopropylpyrophosphoramide) 1 mg/kg sc 1 h before the soman administration, ca
To estimate the potential of small doses of sarin (types I and 11) and soman to cause delayed neuropathic effects, 400, 200, 61, and 0 pglkg of sarin-I, 280, 140, 70, and 0 pglkg of sarin-11, and 14.2, 7.1, 3.5, and 0 pglkg of soman by gavage were compared with 510 mglkg tri-o-cresyl phosphate (TOCP