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Establishment of small molecule-based in silico models for prediction of hERG and Nav1.5 inhibitions for drug discovery

โœ Scribed by Ikemori_Kawada, Megumi; Dodo, Tetsushi; Yu, Melvin; Yoshinaga, Takashi; Inoue, Atsushi; Sawada, Kohei


Book ID
127194482
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
74 KB
Volume
229
Category
Article
ISSN
0378-4274

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[Biotechnology: Pharmaceutical Aspects]
โœ Ehrhardt, Carsten; Kim, Kwang-Jin ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Springer US ๐ŸŒ English โš– 217 KB

In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found