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Establishment of latency in vitro with herpes simplex virus temperature-sensitive mutants at nonpermissive temperature

✍ Scribed by Wrzos, Helena; Rapp, Fred


Book ID
122600599
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
527 KB
Volume
8
Category
Article
ISSN
0168-1702

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Primary rat embryo cells were transformed by a tsA mutant (tsA640) of simian virus 40 (SV40). Proliferation of all four independent diploid transformants was suppressed at a nonpermissive temperature (40.3\*C), being accompanied by a marked increase in the fraction of cells with a 4N DNA content (a